Studies of polymorphic variants of candidate genes in the kalmyk cattle breed population
https://doi.org/10.53315/2949-1231-2023-2-3-22-27
Abstract
Analysis of these results from PCR-RFLP of Kalmyk breed bulls at the GH and Tg5 locus in breeding breeders of the Republic of Kalmykia determined the following: for the GH gene, out of 86 samples, 44% were carriers of the homozygous VV genotype, 26% of animals became carriers of the heterozygous LV genotype, and with the homozygous genotype LL they numbered 30%. For the Tg5 gene, out of 80 samples, 31% are carriers of the homozygous TT genotype, 48% of animals were carriers of the heterozygous TG genotype, 21% of animals were carriers of the homozygous GG genotype. The percentage of desirable genotypes associated with economically valuable productivity indicators — VV and TT, do not differ significantly (44% and 31%, respectively) among themselves and are at an average level. This can be explained by targeted selection and breeding work in the studied herds.
About the Authors
N. V. ChimidovaRussian Federation
Сandidate of Biological Sciences, Associate Professor
Elista
L. G. Moiseikina
Russian Federation
Doctor of Biological Sciences, Associate Professor
Elista
В. К. Bolaev
Russian Federation
Doctor of Agricultural Sciences, Professor
Elista
A. V. Ubushieva
Russian Federation
Laboratory researcher molecular genetics Republican Scientific and
Practical Center for the reproduction of farm animals
Elista
А. В. Avsheeva
Russian Federation
Master’s student
Elista
References
1. Banos G, Winters M, Mrode R, Mitchell AP, Bishop CS, Woolliams JA, Coffey MP. Genetic evaluation for bovine tuberculosis resistance in dairy cattle // Journal of Dairy Science. 2017; 100(2):1272- 1281. doi.org/10.3168/jds.2016-11897
2. Bayram D, Akyüz B, Arslan K, Özdemir F, Aksel EG, Çinar MU. DGAT1, CAST and IGF-I gene polymorphisms in akkaraman lambs and their effects on live weights up to weaning age // Kafkas Universitesi Veteriner Fakultesi Dergisi. 2019;25(1):9-15. doi: 10.9775/ kvfd.2018.20055
3. Bouwman AC, Daetwyler HD, Chamberlain AJ, Ponce CH, Sargolzaei M, Schenkel FS, et al. Meta-analysis of genome-wide association studies for cattle stature identifies common genes that regulate body size in mammals // Nat Genet. 2018;50:362–367. doi: 10.1038/s41588- 018-0056-5.
4. Beishova I.S., Ulyanov V.A., et al. Features of holstein cattle bred in kazakhstan by the polymorphic genes of the somatotropin cascade // Advances in Animal and Veterinary Sciences. 2019. Vol. 7. No. Special Issue 1. P. 60-65. doi: 10.17582/journal.aavs/2019/7.s1.60.65.
5. Gadzhiev Z.K., Surzhikova E.S., Mikhailenko T.N., Evlagina D.D. Studying and DNA testing of farm animals for genes that determine productive qualities: guidelines // Stavropol: OOO Stavropol-Service-School, 2022. 78 p. ISBN 978-5-6048650-3-3.
6. Hickl D., Scheuring D., Möhlmann T. CTP Synthase 2 From Arabidopsis thaliana is required for complete embryo development // Frontiers Plant Sci. 2021. V. 12. P. 652434.
7. Krivoruchko A.Yu., Yatsyk O.A., Safaryan E.Yu. Productivity candidate genes identified during a genome-wide search for associations with class indicators in Russian meat Merino sheep // Vavilov Journal of Genetics and Breeding. 2020;24(8):836-843.
8. Krivoruchko A.Yu., Zuev R.V., Surov A.I. and others. Genome-wide search for new candidate genes for meat productivity in sheep of the North Caucasian meat-wool breed // Genetics, 2023, T. 59, No. 5, pp. 562-572. doi: 10.31857/S0016675823050090
9. Kolpakov V.I., The influence of some polymorphic genes on meat productivity and meat quality in cattle (review) // Animal husbandry and feed production 2020 T. 103 No. 4. doi: 10.33284/2658-3135-103-4-47
10. Liu S, Gao Y, Canela-Xandri O, Wang S, Yu Y, Cai W, et al. A multi-tissue atlas of regulatory variants in cattle // Nat Genet. 2022;54:1438–1447. doi: 10.1038/s41588-022-01153-5.
11. Marie-Pierre Sanchez, Thierry Tribout, Naveen K Kadri, et al. Sequence-based GWAS meta-analyses for beef production traits // Genet Sel Evol. 2023 Nov 13;55(1):79. doi: 10.1186/ s12711-023-00852-9.Genet Sel Evol. 2023.
12. Nissinen T.A., Hentilä J., Fachada V. et al. Muscle follistatin gene delivery increases muscle protein synthesis independent of periodical physical inactivity and fasting // The FASEB J. 2021. V. 35. № 3. P. e21387. https://doi.org/10.1096/fj.202002008R
13. Nimbona C, Kulikova NI, Butore J, Ntunzwenimana M. The results of the embryo transfer to heifers from the ayrshire breed // RUDN Journal of Agronomy and Animal Industries. 2019;14 (1):66-72. doi: 10.22363/2312-797X-2019-14-1-66-72
14. Surundaeva L.G. Allelic polymorphism of the thyroglobulin gene in beef cattle // Bulletin of Beef Cattle Breeding 2016 No. 3(95)
15. Shirokova, N.V. Genetic structure of the herd by genes gdf9, gh, cast in merino sheep of the north caucasus region of Russia // В сборнике: IOP Conference Series: Earth and Environmental Science. Krasnoyarsk Science and Technology City Hall. Krasnoyarsk, Russian Federation, 2021. 52-56
Review
For citations:
Chimidova N.V., Moiseikina L.G., Bolaev В.К., Ubushieva A.V., Avsheeva А.В. Studies of polymorphic variants of candidate genes in the kalmyk cattle breed population. The Agriculture and Ecosystems in Modern World: Regional and Inter countries’ research. 2023;2(3):22-27. (In Russ.) https://doi.org/10.53315/2949-1231-2023-2-3-22-27